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Calm Breath, Calm Mind: A Guide to the Healing Power of Breath

為了解決The Eminence in Shad的問題，作者Losar, Geshe Yongdong 這樣論述：

Geshe YongDong Losar (Geshela) is a Tibetan Bön lama, or spiritual teacher, in the Yungdrung Bön lineage, which is rooted in the indigenous spiritual tradition of the Himalayas. He lives in Courtenay, British Columbia, where he established and directs Sherab Chamma Ling, the only Tibetan Bön Buddhis

t center in Canada. He teaches in many centers and universities around the world and has also founded the Bon Da Ling center in Costa Rica. Geshe YongDong has published several books in Tibetan and is an active member of Chiling Bon Tsok, the International Bon Lamas Association, and the Internation

al Tibetan Non-Sectarian Religious Association. He is cherished by students and colleagues for his calm and loving manner, his humor and humility, and his tireless dedication to the Dharma and the ultimate liberation of hearts and minds. Geshe YongDong was born in 1969 in the Ngawa County of Amdo i

n northeastern Tibet. As a boy, his desire to become a monk was intensified by the death of his mother, the death of his grandmother, and the three years he spent alone in the harsh Himalayan mountains tending a flock of over six hundred sheep for his uncle. At the age of thirteen his uncle finally

allowed him to enter the Nangzhig Monastery in Amdo, the largest Bon monastery in Tibet, where he studied under the venerable master Geshe Wako Gyaltsen, Yongdzin Yeshe Gyaltsen, and Jetsun Namkha Tsultrim. Eleven years later, after completing specialized training in all aspects of the Dharma, he w

as awarded the geshe degree, an academic achievement of the highest order, similar to a Western PhD in theology. He escaped Tibet soon after, settling in India where he had the honor of receiving teachings from three of the most eminent spiritual leaders of our time: His Holiness the Dalai Lama; His

Holiness the 33rd Menri Trizin, the spiritual leader of Bön; and His Eminence Yongdzin Tenzin Namdak Rinpoche, the senior teacher and lineage holder of Bön. Geshe YongDong spent another three years studying at Sera Monastic University in India before relocating to Canada. Bernadette Wyton has rece

ived teachings from His Holiness the Dalai Lama, His Holiness the late 33rd Menri Trizin, Khenpo Tenpa Yungdrung, and His Eminence Yongdzin Tenzin Namdak Rinpoche, and remains a grateful witness to the clarity of their wisdom, the excellence of their teachings, and the blessing that flows through th

em for the benefit of all. Bernadettemet Geshe YongDong in 2002 while he was teaching a course on meditation at the college in her hometown of Port Alberni, British Columbia. She has been his student ever since and has served as his writing assistant for the last ten years. Bernadette has a BSc in

marine biology and has worked in that field and in many other areas of environmental protection, including airshed management, forest practices, and the global impact of oil and gas extraction. She lives with her husband on Vancouver Island, where they enjoy the ocean, growing their own food, and be

ing with their children and grandchildren. Founder and spiritual director of Ligmincha International, Geshe Tenzin Wangyal Rinpoche is a respected and beloved teacher and meditation master in the Bön tradition of Tibet. He has students in more than twenty-five countries, teaches around the world and

reaches thousands of students through his online programs. Trained as a Bön monk, Rinpoche now lives as a householder, allowing him to more fully relate to the needs and concerns of his students. Known for the depth of his wisdom and his unshakeable commitment to helping students recognize their tr

ue nature, he is the author of many books and online courses.

Sir John Plumb: The Hidden Life of a Great Historian

為了解決The Eminence in Shad的問題，作者McKendrick, Neil 這樣論述：

Sir John (Jack) Harold Plumb (1911 - 2001) was a great British historian. He led an extraordinary life of startling contrasts, much of it cloaked in secrecy. This memoir attempts to lift that cloak. / This is a very personal account written by Neil McKendrick, a fellow historian, a fellow Master

of a Cambridge college and one his oldest and closest friends, who knew Plumb from his early days to his dying hours some fifty years after they first met. / This new memoir depicts a startlingly revelatory portrait of a complex and controversial man who moved from poverty to great affluence; from b

eginning his life in a two-up two-down terrace house in Leicester to end it in what was called ＂Jack’s Palace＂ surrounded by a world-class collection of Vincennes and Sèvres. / Plumb’s personality was sufficiently beguiling to attract the attention of four significant novelists who left six vivid if

unflattering fictional versions of him - depicting him as a ruthless charmer, a serial bisexual philanderer and, most bizarrely of all, as a murderer planning a further murder. In truth the real man needed no fictional elaboration to make him unusually interesting. In fact his life is often astonis

hing. The historian, who achieved such international eminence that, on the direct order of the US President and after a unanimous vote in Congress, the Union flag was flown over the American Congress on his 80th birthday to do honour to the historian who had taught the American people so much, was n

o run of the mill academic. / In addition to his academic work, during the Second World War Plumb worked in the code-breaking department of the Foreign Office at Bletchley Park, Hut 8 & Hut 4; later Block B. He headed a section working on a German Naval hand cipher, Reservehandverfahren. He beca

me Professor of Modern English History at Cambridge in 1966, serving as Master of Christ’s College from 1978-82, when he was knighted in 1982. His pupils included Simon Schama, Roy Porter, Niall Ferguson and David Cannadine. / Plumb had moved from drinking beer in down-market pubs in his youth to dr

inking champagne in aristocratic drawing rooms and owning the finest collection of claret in Cambridge; from a passionate socialist for most of his life (with, at one time, strong Communist sympathies) to a passionate Thatcherite in his 70s; from his provincial working class family in Leicester to b

ecome a close friend of the Rothschilds and a companion of the Queen’s sister who gave a memorable 80th birthday party for him in her home at Kensington Palace Gardens. / He moved from a Cambridge college reject in his youth to the Mastership of Christ’s; from a rejected author (of both a novel and

his early research) to an acclaimed and prolific writer, editor and journalist; from a conventional heterosexual youth in Leicester to an opportunistic bisexual life thereafter; from his life-enhancing and inspiring best to his embittered worst in extreme old age; from his infancy when he was wet-nu

rsed by a friend of his mother’s to his funeral when he was buried without mourners or music or elegies or even a coffin. For all his achievements, his life also encompassed failure and disappointments and its end was almost unbearably sad. / This memoir is an attempt to do for Plumb what a relative

of Lord Macaulay once did for that great historian, when he wrote: ＂There must be tens of thousands whose interest in history and literature he has awakened and informed by his pen, and who would gladly know what manner of man it was that has done them so great a service＂. The ＂manner of man＂ that

emerges from this book is as fascinating as it is surprising. /

NDEL1原發突變p.R105P在平腦症與神經遷移異常中所扮演的角色

為了解決The Eminence in Shad的問題，作者柯皓禎 這樣論述：

在大腦皮質發育的過程中，神經幹細胞會先以一種稱為「內動性核遷移」的波動方式在腦室區增生，隨後這些細胞遷移經中間區至皮質，最後分化為不同神經細胞以組成大腦皮層。一旦這種複雜的過程被外因性細胞訊號或內因性基因突變所干擾，就可能基於神經細胞無法順利遷移到正確位置，而導致平腦症這種皮質發育畸形的疾病，並進一步出現癲癇及智能發展遲緩等症狀。NDEL1過去又被稱為NUDEL，是一種在胞質動力蛋白複合體中協助大腦皮質發育時進行神經遷移的蛋白。透過次世代定序，我們在平腦症病人身上找到了第一個NDEL1突變p.R105P，本研究因此希望能釐清這個原發性NDEL1錯義突變在平腦症上的致病機轉，以及是否會造成神經

遷移遲緩。為了探討NDEL1在大腦皮質發育中的角色，我們在小鼠胚胎大腦中的神經幹細胞使用子宮內電穿孔來降低Ndel1表現、或是過度表現Ndel1野生型與突變型，並藉此發現突變型Ndel1不僅無法補償將Ndel1減弱後的效果，甚至會造成更嚴重的神經遷移遲緩，代表此突變型Ndel1可能是一種顯性抑制突變。同時，我們也在表現突變型Ndel1的神經細胞中觀察到前導突起的長度，以及核距離中心體的長度皆有增長之情形。我們更進一步透過免疫共沉澱法發現突變型Ndel1無法順利與原應被招募至胞質動力蛋白複合體上的Lis1與Katnb1兩種蛋白產生交互作用。這些研究結果揭示了突變型NDEL1導致平腦症發生的機轉為

干擾NDEL1和LIS1與KATNB1之間的交互作用，並進一步影響胞質動力蛋白複合體本身的功能，最後造成神經遷移遲緩。