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End Game: Does Israel Have a Plan?

為了解決Be different from的問題，作者Sachs, Natan 這樣論述：

How Israelis envision and plan for the future of their countryDoes Israel have a plan? What does the country want to look like in 10 or 20 years? What borders does it hope to have? Will the West Bank or the Gaza Strip be part of it? Will the Palestinians residing the territories be granted citizensh

ip and become Israeli citizens? Does the country as a whole even know what it wants, what its goals are, or how to achieve them?Israel faces a fundamental question, a "trilemma." It can choose only two of three different goals many Israelis hold dear: to maintain control over the West Bank, with its

strategic and religious significance to Israel; to retain a clear Jewish majority, the goal of the Zionist movement that founded the state; or to remain a democracy, with full voting rights for all citizens.This trilemma has caused world leaders and publics, Israel-supporters and critics, to wonder

aloud time and again: what does Israel want? If it wishes to maintain its Jewish and democratic character, surely it must separate from the West Bank and its population; why then does Israel keep building in Israeli settlements in the West Bank, making such separation all the more difficult? And if

it plans to retain control over the West Bank, is it really willing to give up on either its Jewish nature or its democracy?End Game attempts to solve the puzzle of why the Israeli strategic vision seems so elusive to many foreigners and Israelis alike. It explores how Israelis' beliefs about their

future are formed and how their visions are translated into policy, focusing on three factors in depth: the role of security concerns, ideology, and domestic political constraints that combine to shape Israel's strategic posture.The book contrasts the full range of views in Israel over the future o

f the West Bank, from supporters of a bi-national state or confederacy on the left, to supporters of a "one state" on the far right of the political spectrum. It pays particular attention to the worldview of the political center-right, led by Prime Minister Benjamin Netanyahu, a conservative, risk-a

verse and "anti-solutionist" approach to the problem. This worldview, following decades of precedent, rejects the need for a full-fledged strategic "solution" to the problem, leading to widespread confusion over Israel's goals. The book analyses and critiques this approach, arguing forcefully for en

ding Israeli indecision over the future of the land and in favor of partition and, eventually, peace. Dr. Natan Sachs is a fellow in the Center for Middle East Policy at the Brookings Institution. His research focuses on Israel’s foreign policy, its domestic politics, and on U.S.-Israeli relations

. Before joining Brookings, Sachs was a Hewlett Fellow at Stanford’s Center on Democracy, Development and the Rule of Law, a Fulbright Fellow in Indonesia, and a Visiting Fellow at Tel Aviv University’s Dayan Center for Middle Eastern and African Studies.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Be different from的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

American Manhood: A Concise History of Masculinity in U.s. History and Culture

為了解決Be different from的問題，作者Carroll, Bret 這樣論述：

While the concepts of manhood and masculinity have assumed an established place in gender and historical studies and masculinity is the subject of wide popular interest and discussion, there is currently no up-to-date, comprehensive historical overview of the subject. American Manhood will introd

uce readers to the dynamic interplay between the perceptions and experiences we call "masculinity" and major social, cultural, political, and economic developments in our history. Its central argument will be that Americans of different racial, class, ethnic, and regional groups have historically us

ed concepts of masculine identity to gender relations of power and national belonging in ways that attempt either to entrench or to stake their claims to positions of authority and legitimacy in American life. Gender, the book assumes and will demonstrate, provides a crucial analytic category for un

derstanding U.S. history. The book will cover the period from roughly the early seventeenth century to the present. It will utilize a combination of chronological and topical approaches to present a state-of-the-art narrative, reflective of current historical scholarship, to a broad general audience

. The anticipated audience will bring to their reading a familiarity with recent popular discussions of masculinity; American Manhood will use accessible prose to reveal to them the enormous complexity, diversity, and historical rootedness of the topic - to deepen readers' understanding of a subject

they thought they knew.

探討數位科技導入餐飲服務業對於消費者服務體驗之影響

為了解決Be different from的問題，作者張雅涵 這樣論述：

數位革命成為一股強大的變革力量，然而大多數的研究討論上亦聚焦於導入數位科技對廠商之優勢和效益，卻少以從消費者視角深入地探討心理感受。因此，本研究首先透過文獻綜整分析針對餐飲業將不同數位科技進行分類，並整理說明這些不同類型數位科技之特性，進而運用消費者深度訪談分析這些科技運用對於消費者接觸時所產生之感受和體驗，欲歸納出消費者在面對各類型餐飲數位科技服務的不同服務情境所產生的可能正反面感受。研究結果發現在服務前、中，主要優點是省時、便利、舒適自在。在服務後，其主要優點有輕便方便、舒適自在、自主性。再者，個人的心理也產生截然不同的缺點，在服務前，主要缺點分別為:系統介面未優化、缺乏溫度真實感、服務

介面制式化、疏遠性。而在服務中的有:缺乏溫度真實感、使用介面不流暢、功能單一化。至於在服務後，強迫不適感、時差性、資料安全疑慮盜刷風險上述三個為主要缺點。最後，本研究貢獻方面，在實務管理意涵上，期望透過這些結果能供業者在導入數位科技於服務流程中之商業價值，以提供餐飲業者在擬定服務創新策略時之參考。