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Civic Ritual, Commemoration and Public Celebration in Urban Britain, 1850-1950

為了解決Ben的問題，作者Roberts, Ben 這樣論述：

Ben Roberts is Part-Time Lecturer at Teesside University, UK.

Ben進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Ben的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

The Sage in Relation: Familial Descriptions of the Sage in the Scribal Circles of Ben Sira and Cognate Literature

為了解決Ben的問題，作者Montanaro, Andrew 這樣論述：

Die Reihe Deuterocanonical and Cognate Literature Studies (DCLS) widmet sich vornehmlich der Erforschung der Bücher der griechischen Bibel (Septuaginta), die nicht im hebräischen Kanon enthalten sind, sowie der zwischentestamentlichen und der frühen jüdischen Literatur aus der Zeit vom 3. Jahrhun

dert v.Chr. bis zum 2. Jahrhundert n.Chr. Die Reihe wurde 2007 in Zusammenarbeit mit der ＂International Society for the Study of Deuterocanonical and Cognate Literature＂ eröffnet. Sie bildet die passende Ergänzung zum Deuterocanonical and Cognate Literature Yearbook, das seit 2004 erscheint.

公有雲端企業資料庫即時同步備援到企業自有機房之研究

為了解決Ben的問題，作者周建竹 這樣論述：

由於在近十年來網路通訊技術的快速發展，雲端服務在手機時代已經被各企業和個人所採用，在此平台上，提供的服務，可以使租用戶能快速建構符合他們本身所需要的資料系統，另外在以前雲端服務及網路通訊技術尚未普及的年代，資訊系統備援是有地區距離的限制，而現在，在地端和雲端聯結更緊密的時代，在雲端各應用系統的後端的關聯式資料庫儲存重要的交易資料，其中備援設計更是極為重要。在本論文中研究的目的將以雲端的關聯式資料庫層級即時備援到地端，從可用性、即時性、保密安全性、持久性保存和搬遷性等做探討，本研究所採用的方式為在雲端租用和設定環境和地端架設環境，建構本研究之研究模型，進行雲端到地端在關聯式資料庫層級的備援探討

分析，並使用雲端運算業者Azure的計量統計圖表做資料蒐集及資料分析，呈現雲端硬碟讀寫累積使用量和網路頻寬累積使用量的數據並進行分析和探討，企業將可依照自己業務特性，做出符合最佳化的雲端資料庫備援到地端資料庫方式的決策。