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Differential Diagnoses in Surgical Pathology: Non-Neoplastic Dermatopathology

為了解決Comparison between的問題，作者Cook, Deborah L. 這樣論述：

Offering expert, practical guidance through the decision-making process, Differential Diagnoses in Surgical Pathology: Non-Neoplastic Dermatopathology, by Dr. Deborah L. Cook, helps you systematically solve tough diagnostic challenges in skin pathology and arrive at a correct diagnosis between co

mmonly confused entities. In this all-new title, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the aut

hor emphasizes atypical features that can complicate diagnoses. Provides side-by-side comparisons for each major differential diagnosis, helping you distinguish between commonly confused non-neoplastic dermatopathology lesions Contains more than 850 full-color photographs that depict the features of

each entity and cover major differential diagnoses in this challenging area Covers inflammatory disorders and alterations of the epidermis and dermis, blistering diseases, disorders of the adnexae and subcutis, infectious diseases, and more Ideal for practicing pathologists, pathologists in trainin

g, residents, and medical students Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Comparison between的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Radical Realism, Autofictional Narratives and the Reinvention of the Novel

為了解決Comparison between的問題，作者Doloughan 這樣論述：

This monograph is concerned with what it sees as two complementary phenomena: that of contemporary writers of fiction who seem to have turned their backs on the traditional novel in favour of what might be termed a radical realism, alongside a more general movement towards and interest in auto/bi

ography and memoir in the post-truth era. By reviewing the work of four authors whose trajectory to date represents engagement with novelistic as well as auto/biographical forms, it reconsiders differences between ’fiction’ and ’non-fiction’, as they pertain to both production and reception, includi

ng issues of generic categorization, the prevalence or exclusion of specific textual markers, and readerly expectations in navigating diverse and shifting literary cultures.The Norwegian author Karl Ove Knausgaard’s Min Kamp (My Struggle) series is considered in English translation in relation to it

s cross-cultural reception; it is also placed within the context of Knausgaard’s oeuvre as a whole. Some parallels between the work of Knausgaard and that of Rachel Cusk are drawn, though in the case of the latter the focus is not so much on the memoirs but on the Outline trilogy that followed the t

rilogy of memoirs and the extent to which it represents both a departure from and a continuation of some of the concerns expressed in previous non-fictional works with a specific focus on Aftermath. Comparison of Jeanette Winterson’s semi-autobiographical debut novel, Oranges Are Not the Only Fruit,

with her memoir entitled Why Be Happy When You Could Be Normal? allows for close textual reading of scenes initially treated in novelistic form and revisited in the memoir permitting discussion of points of similarity and difference in their treatment in relation to the constraints and affordances

of genre, where these apply. Discussion of Xiaolu Guo’s memoir, Once Upon A Time in the East, focusses both on its cross-cultural reception and on the place of the memoir within the Guo corpus.In some ways all four writers are less concerned with traditional aspects of story and more concerned to de

ploy a range of forms, including narrative, to serve their interest in broader questions of truth, agency and self-understanding.

探討認知師徒制融入數位學習之學習成效及自主學習行為-以醫放系實習生學習上腹部超音波病灶辨認為例

為了解決Comparison between的問題，作者蘇于珊 這樣論述：

近幾年，受到疫情的影響使得數位學習在教學領域上的應用愈來愈普遍，數位學習運用在醫學領域相關課程的學門逐漸受到重視。醫院放射科的超音波技術非常重視實作經驗及影像辨認，一向使用師徒制的方式來進行教學，每位實習生所遇到的病灶量與質有差異，且學習過程缺少了反思和探索。因此本研究運用融入認知師徒制之數位學習來進行上腹部超音波病灶之教學，以到醫院實習的醫放系22位實習生為研究對象，希望能藉此提升實習生辨認超音波病灶的學習成效、並探討其學習滿意度及自主學習行為。結果發現運用數位學習上腹部超音波的方式確實能夠提升實習生辨認超音波病灶的學習成效，且整體學習滿意度頗佳，自主學習能力也有提升學習滿意度及自主學習之

間具有顯著相關，且學生的自主學習能力與專題報告也呈現顯著正相關。建議臨床教師推動數位學習融入超音波實習課程，可採用同步線上課程和非同步線上課程的搭配方式及利用線上討論和通訊軟體提供互動活動，未來研究可融入自主學習策略於教學探討對學生自主學習行為和能力的幫助。