Discussion的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列線上看、影評和彩蛋懶人包

Essays on Aristotle’s Eudemian Ethics

為了解決Discussion的問題，作者Heinaman, Robert (EDT) 這樣論述：

Two major works on ethics have come down to us under Aristotle's name, the Nicomachean Ethics and the Eudemian Ethics, but, quite unjustifiably, the Eudemian Ethics has been largely neglected by students of ancient philosophy. This important collection of essays from the sixth Keeling colloquium on

ancient philosophy tries to rectify this one-sided approach to Aristotle's ethics by focusing on the positions and arguments of the Eudemian Ethics. As the essays demonstrate, Aristotle's views in the Eudemian Ethics frequently differ in interesting and surprising ways from those found in the Nicoma

chean Ethics and deserve study for their own sake, not merely for purposes of comparison with the Nicomachean Ethics. The contributors include some of the best known Aristotle scholars of the present day. Christopher Rowe and Jennifer Whiting investigate the Eudemian Ethics' account of friendship (p

hilia) while M.M. McCabe examines the closely related issue of self-knowledge in EE VII.12. Stephen White analyzes the Eudemian Ethics' account of eudaimonia, David Charles focuses on voluntary action, and Friedemann Buddensiek investigates Aristotle's difficult discussion of good fortune (eutuchia)

in EE VIII.2. The volume also contains critical discussions of these papers provided by commentators, who, along with Whiting and McCabe, include Julia Annas and Sarah Broadie. Dr Robert Heinaman, Reader in Philosophy, University College London, UK

Discussion進入發燒排行的影片

沙氏法對收益結構和績效之影響：臺灣會計師產業的證據

為了解決Discussion的問題，作者陳劍雄 這樣論述：

美國於2002年7月發布沙氏法案(The Sarbanes-Oxley Act of 2002, SOX)，SOX法案及其精神導致會計師產業發生重大變化。本文探討SOX與會計師產業收益結構和績效之關聯性，使用臺灣「1992-2019年會計師事務所服務業調查報告」的22,356筆觀察資料，透過收益函數來探討SOX對會計師產業之總收益、傳統服務份額、稅務服務份額和管理諮詢服務份額之影響。同時，本研究依樣本類型分為小型、中型、大型和國際型會計師事務所，從經濟管制理論(Theory of Economic Regulation, TER)的角度，考察SOX管制制度對會計師事務所績效之影響。我們運用會

計師產業的translog收益函數，並建立了迴歸方程式來檢驗我們的假說。本研究發現SOX法案對非國際型會計師事務所的收益產生了消極影響，但對國際型會計師事務所的收益產生了積極影響。SOX法案增加了非國際型會計師事務所的稅務服務份額，同時也增加了國際型會計師事務所的稅務服務份額。此外，我們還發現SOX法案對四種不同規模的會計師事務所的經營績效都存在正向影響。進一步的結果表明，在SOX管制之下，大型和國際型會計師事務所直接獲得了管制的利益(直接管制效應)，小型和中型事務所間接獲得管制的利益(間接管制效應)。本研究有助於文獻研究，為監管機構完善會計師事務所管理提供啟示。

American Manhood: A Concise History of Masculinity in U.s. History and Culture

為了解決Discussion的問題，作者Carroll, Bret 這樣論述：

While the concepts of manhood and masculinity have assumed an established place in gender and historical studies and masculinity is the subject of wide popular interest and discussion, there is currently no up-to-date, comprehensive historical overview of the subject. American Manhood will introd

uce readers to the dynamic interplay between the perceptions and experiences we call "masculinity" and major social, cultural, political, and economic developments in our history. Its central argument will be that Americans of different racial, class, ethnic, and regional groups have historically us

ed concepts of masculine identity to gender relations of power and national belonging in ways that attempt either to entrench or to stake their claims to positions of authority and legitimacy in American life. Gender, the book assumes and will demonstrate, provides a crucial analytic category for un

derstanding U.S. history. The book will cover the period from roughly the early seventeenth century to the present. It will utilize a combination of chronological and topical approaches to present a state-of-the-art narrative, reflective of current historical scholarship, to a broad general audience

. The anticipated audience will bring to their reading a familiarity with recent popular discussions of masculinity; American Manhood will use accessible prose to reveal to them the enormous complexity, diversity, and historical rootedness of the topic - to deepen readers' understanding of a subject

they thought they knew.

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Discussion的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.