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Pierre Gassendi: Humanism, Science, and the Birth of Modern Philosophy

為了解決It is of importance的問題，作者Bellis, Delphine (EDT)/ Garber, Daniel (EDT)/ Palmerino, Carla R 這樣論述：

Pierre Gassendi (1592-1655) was a major figure in seventeenth-century philosophy whose philosophical and scientific works contributed to shaping Western intellectual identity. Among "new philosophers," he was considered Descartes' main rival, and he belonged to the first rank of those attempting to

carve out an alternative to Aristotelian philosophy. Given the importance of Gassendi for the history of science and philosophy, it is surprising to see that he has been largely ignored in the Anglophone world.This collection of essays constitutes the first book on Gassendi that comprehensively cove

rs his biography, bibliography, and all aspects of his philosophy. The book is divided into four parts. It begins with a brief sketch of the intellectual world of seventeenth-century France, Gassendi's early attacks on Aristotle, and a bibliographical essay on early-modern publications of Gassendi's

writings. Part II explores Gassendi's contributions to logic, natural philosophy, and astronomy and cosmology. Part III addresses Gassendi as a humanist and participant in seventeenth-century philosophical and scientific debates, including his advocacy of Epicurean philosophy and his relation to th

e sceptical tradition. The fourth and final part involves a brief discussion of the reception of Gassendi's thought, including the paraphrases of his works published in France and England. This book is an essential resource for scholars and upper-level students of early modern philosophy, intellectu

al history, and the history of science who want to get acquainted with Pierre Gassendi as a major philosopher and intellectual figure of the early modern period. Delphine Bellis is a postdoctoral researcher of the Research Foundation Flanders (FWO) at Ghent University, Belgium. Her research mainl

y focuses on Descartes, Gassendi, and early modern optics and matter theory.Daniel Garber is Stuart Professor in the Department of Philosophy at Princeton University, USA. He has written widely on issues relating to the history of philosophy and science in the early modern period. His books include

Descartes’ Metaphysical Physics, Descartes Embodied, and Leibniz: Body, Substance, Monad. With Michael Ayers, he is the co-editor of the Cambridge History of Seventeenth-Century Philosophy.Carla Rita Palmerino is full Professor in the History of Modern Philosophy at Radboud University, Nijmegen, the

Netherlands. Her research mainly focuses on early modern theories of matter and motion and she has published several articles on Gassendi’s natural philosophy.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決It is of importance的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Special Functions in Fractional Calculus and Related Fractional Differintegral Equations

為了解決It is of importance的問題，作者Srivastava, Hari M. 這樣論述：

The subject of fractional calculus (that is, calculus of integrals and derivatives of any arbitrary real or complex order) has gained considerable popularity and importance during the past four decades, due mainly to its demonstrated applications in numerous seemingly diverse and widespread field

s of science and engineering. It does indeed provide several potentially useful tools for solving differential, integral and differintegral equations, and various other problems involving special functions of mathematical physics as well as their extensions and generalizations in one and more variab

les.Many books and monographs (and conference proceedings) deal with the subject of fractional calculus and its applications. However, to the best of our knowledge, there does not exist an exclusive work that co-ordinates the disciplines of fractional calculus and special functions in a potentially

useful manner. This book is an attempt in that direction and would serve a dual purpose: in providing key formulas and identities involving special functions and also in opening up some novel avenues of applications of fractional calculus.

資訊安全事件管理平台的自動化聯合防護阻擋機制之研究

為了解決It is of importance的問題，作者劉鍵毅 這樣論述：

隨著台灣資通安全意識提升，國內許多企業、法人或公務機關，逐漸重視資訊安全的防護，導入資訊安全事件管理平台，使網路活動及日誌可視化，並集中於同一平台上，讓資安管理人員能直接在SIEM平台上直接看見許多設備的日誌，平時除了能主動查找異常日誌外，也能被動地建立規則條件及門檻值（Threshold）使日誌被規則關聯。在有了告警功能後，管理者便可以一目了然的看見告警的原因，再經由人工判斷，判斷是否需要將該事件的IP新增到具有阻擋功能之設備進行阻擋，或向具阻擋功能之資安設備管理者申請阻擋。本研究將實作開發自動化聯防阻擋程式，並在資訊安全事件管理平台上建立相關規則，並利用模擬真實事件發生時的日誌，在資訊安

全事件管理平台上模擬出設備日誌，將資訊安全事件管理平台所觸發相關規則之事件IP，透過自動化阻擋程式，將IP送至入侵偵測防禦系統（Intrusion Prevention System, IPS）黑名單進行阻擋，以符合自動化阻擋機制，並將阻擋程式之日誌送至SIEM進行監控，最後將整體機制呈現於結果。