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Diseases of Horticultural Crops: Diagnosis and Management: Volume 4: Important Plantation Crops, Medicinal Crops, and Mushrooms

為了解決K ONE JR的問題，作者 這樣論述：

J. N. Srivastava, PhD, is currently Associate Professor cum Senior Scientist (Plant Pathology) at Bihar Agricultural University, Sabour, Bhagalpur, Bihar, India. Formerly, he was Assistant Professor/Jr. Scientist (Plant Pathology) at Sher-e-Kashmir University of Agriculture Sciences and Technology,

Jammu and Kashmir, India. He has acted as Principal Investigator and Co-Principal Investigator for several projects on biological control/ integrated disease management. In addition to teaching and research, he is also engaged in various agriculture extension activities, such as farm advisory servic

es, including video conferencing, radio and TV talks, vocational training for the rural youth skill, entrepreneurship development programs, farmer training, in-service training, etc. Dr. Srivastava has published many research papers in both Indian and international journals, book chapters, extension

articles, practical and technical bulletins, and leaflets. He was the recipient of many awards for achievement and teaching, including an Excellence in Teaching Award (2017), Excellence in Science Communication Award (2017), Distinguished Faculty Award (2017), Eminent Scientist Award (2018), etc. H

e is a member of many academic and scientific organizations and is associated with many international, national, and provincial scientific, cultural, and academic/educational bodies, while also serving as an editorial board member of the International Journal of Plant Protection. He is also a review

er for various scientific journals.A. K. Singh, PhD, is Assistant Professor in the Division of Plant Pathology at Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu and Kashmir, India. He has been engaged for more than 12 years in teaching (both undergraduate and postgraduate l

evels) and research and also involved in the transfer of technology through different extension activities. He has published more than 30 research papers in national and international journals of repute, one practical manual, and several book chapters and popular articles and has presented many rese

arch papers at international, national and regional symposiums and seminars. He is a recipient of several prestigious awards for his research contributions. Also he served as a member of the editorial board of Krishi Vikas Patrika, published by the Directorate of Extension, SKUAST of Jammu. He is a

member of several societies of plant pathologists in India.

K ONE JR進入發燒排行的影片

沙氏法對收益結構和績效之影響：臺灣會計師產業的證據

為了解決K ONE JR的問題，作者陳劍雄 這樣論述：

美國於2002年7月發布沙氏法案(The Sarbanes-Oxley Act of 2002, SOX)，SOX法案及其精神導致會計師產業發生重大變化。本文探討SOX與會計師產業收益結構和績效之關聯性，使用臺灣「1992-2019年會計師事務所服務業調查報告」的22,356筆觀察資料，透過收益函數來探討SOX對會計師產業之總收益、傳統服務份額、稅務服務份額和管理諮詢服務份額之影響。同時，本研究依樣本類型分為小型、中型、大型和國際型會計師事務所，從經濟管制理論(Theory of Economic Regulation, TER)的角度，考察SOX管制制度對會計師事務所績效之影響。我們運用會

計師產業的translog收益函數，並建立了迴歸方程式來檢驗我們的假說。本研究發現SOX法案對非國際型會計師事務所的收益產生了消極影響，但對國際型會計師事務所的收益產生了積極影響。SOX法案增加了非國際型會計師事務所的稅務服務份額，同時也增加了國際型會計師事務所的稅務服務份額。此外，我們還發現SOX法案對四種不同規模的會計師事務所的經營績效都存在正向影響。進一步的結果表明，在SOX管制之下，大型和國際型會計師事務所直接獲得了管制的利益(直接管制效應)，小型和中型事務所間接獲得管制的利益(間接管制效應)。本研究有助於文獻研究，為監管機構完善會計師事務所管理提供啟示。

Diseases of Horticultural Crops: Diagnosis and Management: Volume 1: Fruit Crops

為了解決K ONE JR的問題，作者 這樣論述：

J. N. Srivastava, PhD, is currently Associate Professor cum Senior Scientist (Plant Pathology) at Bihar Agricultural University, Sabour, Bhagalpur, Bihar, India. Formerly, he was Assistant Professor/Jr. Scientist (Plant Pathology) at Sher-e-Kashmir University of Agriculture Sciences and Technology,

Jammu and Kashmir, India. He has acted as Principal Investigator and Co-Principal Investigator for several projects on biological control/ integrated disease management. In addition to teaching and research, he is also engaged in various agriculture extension activities, such as farm advisory servic

es, including video conferencing, radio and TV talks, vocational training for the rural youth skill, entrepreneurship development programs, farmer training, in-service training, etc. Dr. Srivastava has published many research papers in both Indian and international journals, book chapters, extension

articles, practical and technical bulletins, and leaflets. He was the recipient of many awards for achievement and teaching, including an Excellence in Teaching Award (2017), Excellence in Science Communication Award (2017), Distinguished Faculty Award (2017), Eminent Scientist Award (2018), etc. H

e is a member of many academic and scientific organizations and is associated with many international, national, and provincial scientific, cultural, and academic/educational bodies, while also serving as an editorial board member of the International Journal of Plant Protection. He is also a review

er for various scientific journals.A. K. Singh, PhD, is Assistant Professor in the Division of Plant Pathology at Sher-e-Kashmir University of Agricultural Sciences and Technology, Jammu and Kashmir, India. He has been engaged for more than 12 years in teaching (both undergraduate and postgraduate l

evels) and research and also involved in the transfer of technology through different extension activities. He has published more than 30 research papers in national and international journals of repute, one practical manual, and several book chapters and popular articles and has presented many rese

arch papers at international, national and regional symposiums and seminars. He is a recipient of several prestigious awards for his research contributions. Also he served as a member of the editorial board of Krishi Vikas Patrika, published by the Directorate of Extension, SKUAST of Jammu. He is a

member of several societies of plant pathologists in India.

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決K ONE JR的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.