韓劇電影你都看哪一部呢？論文書籍站
臺北醫學大學 保健營養學系博士班 黃士懿、陳揚卿所指導 NGAN THI KIM NGUYEN的 Precision nutrition for children with early puberty: leveraging nutrigenomics and lipidomics analysis （2021），提出Mercado BGG關鍵因素是什麼，來自於precocious puberty、central precocious puberty、systematic review、meta-analysis、gene-nutrient interaction、lipidomic analysis、LS/MS、biomarkers。
而第二篇論文國立雲林科技大學 化學工程與材料工程系 鄭宇伸所指導 吳雨珊的 利用靜電技術製備可包覆親脂性生物活性成分愛玉多醣微膠囊及奈米纖維膜 （2020），提出因為有 靜電紡絲、靜電噴霧、薑黃素、愛玉多醣、可快速溶解奈米纖維、微球、藥物傳遞系統的重點而找出了 Mercado BGG的解答。
Precision nutrition for children with early puberty: leveraging nutrigenomics and lipidomics analysis
為了解決Mercado BGG 的問題，作者NGAN THI KIM NGUYEN 這樣論述：
Background: Precocious puberty (PP) is puberty occurring at an unusually early age that brings in adverse health outcomes during adolescence and adulthood. Pubertal development is a complex biological process of sexual development and is affected by genetic, nutritional, environmental, and socio-ec
onomic factors. However, the relationship between pre-pubertal intakes of energy, fat, fiber, protein levels and pubertal timing has been debated. In the genomic era, it is necessary to examine the individual response to a specific diet and how diet influences metabolic regulation in children with P
P personally. Limited evidence investigated the timing of pubertal onset by examining the interaction of nutrient intake and PP-related genetic loci. Importantly, endocrine disorders can alter lipid metabolism. The fact that puberty onset requires critical weight and body fat based on the “critical
weight hypothesis” and many lipid species have been noticed in many human obesity and metabolic syndrome studies. However, a lack of evidence works on lipidomes to propose the based-lipid biomarker and lipid metabolism in predicting PP in children.Methods: By performing a systematic review and meta-
analysis of prospective studies, we aimed to disclose the role of pre-pubertal and pubertal nutrient intake in PP development. Thereafter, we conducted a Taiwan Puberty Longitudinal Study (TPLS) in recruiting adolescents from pubertal and pediatric endocrine clinics in the Northern/Southern part of
Taiwan. The buccal samples for deoxyribonucleic acid (DNA) extraction and genotyping were collected from a total of 1404 children. We will examine the nutrient intake on the interaction with PP-related SNPs on pubertal timing using the “interaction term” of logistic regression. Also, lipidomic analy
sis deriving from 178 subjects’ plasma samples was used to identify the critical lipid biomarkers in diagnosing PP and central precocious puberty (CPP).Results: A high intake of protein, particularly animal protein, monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs) among prepu
bertal girls were significantly associated with PP risk. We also found that SNP rs12617311, rs2090409, and rs12148769 were significantly associated with PP in children. Specifically, different genotypes interacted with such food groups and micronutrient intake. A significant interaction was observed
between intake of vegetables, fruits, fructose and menarcheal loci rs12617311 (PCL1). The rs2090409 (TMEM38B) was more likely to interact with vitamin intake. Importantly, rs12148769 (MKRN3) appeared a significant interaction with saturated FA and MUFA intake. Whist, SNP rs10980921 (ZNF483) showed
a significant interaction with total PUFAs intake. The intake of sucrose, MUFAs, and PUFAs was associated with the potential lipid-based biomarkers, such as Cer(d16:1/22:0), PI(18:2/22:1), and PI(18:2/22:2) of girls and Cer(t20:0/18:0), Cer(d18:1/16:0) and Cer(d18:1/18:1) of boys that could predict
PP and CPP onset. In addition, the lipidomic analysis proposed several candidate lipids metabolism pathways, such as sphingolipid metabolism, steroid biosynthesis, and bile acid biosynthesis for an in-depth lipid mechanism that can be linked to PP and CPP pathophysiology.Conclusion: There was an int
eraction between genetic variant, lipid metabolism, and nutrient intake that was convinced to be associated with PP and CPP development in girls and boys. Nutrient intake may be an important factor in modulating early puberty, especially the consumption of sugar, fructose, and specific saturated fat
ty acids, monounsaturated fatty acids, polyunsaturated fatty acids. Additional research is needed to determine the biological causes of individual variability in response to dietary intake. Likewise, understanding the influence of nutrigenetic interactions on dyslipidemia can aid in the development
and implementation of personalized dietary strategies to improve the PP and CPP treatment.
利用靜電技術製備可包覆親脂性生物活性成分愛玉多醣微膠囊及奈米纖維膜
為了解決Mercado BGG 的問題，作者吳雨珊 這樣論述：
摘要 iABSTRACT iiTable of contents iiiList of tables viList of figures viiChapter 1. Introduction 11.1 Research background 11.2 Objectives 41.3 Layout 4Chapter 2. Literature review 52.1 Microencapsulation of bioactive compound 52.1.1 Curcumin from tumeric (Curcuma longa)
52.1.2 Corn oil for lipid model 72.2 Micro-encapsulation technology 82.2.1 Chemical methods 92.2.2 Physicomechanical methods 102.3 Fast dissolution/disintegration drug delivery system (FD-DDS) 132.3.1 Introduction of fast dissolution/disintegration drug delivery system 132.3.2 Nanofibrous m
ats 132.4 Colon targeted drug delivery system (CDDS) 142.4.1 Introduction of colon targeted drug delivery system 142.4.2 The gelling mechanism of Pectin in CDDS 152.5 Wall materials 162.5.1 Introduction of low methoxyl pectin from jelly fig polysaccharide 162.5.2 Introduction of Pullulan 17
Chapter 3. Materials and experiments 183.1 Materials 183.2 Instruments 183.3 Extraction of jelly fig polysaccharide 203.4 Electrospraying system 213.4.1 Preparation of curcumin-jelly fig microcapsules (C-JFCs) 213.4.2 Conductivity measurement of C-JFCs emulsions 233.4.3 Viscosity m
easurement of C-JFCs emulsions 243.4.4 Calculation of encapsulation efficiency 253.4.5 Optical Microscopy (OM) 283.4.6 Scanning electron microscope (SEM) analysis 283.4.7 Fourier transform infrared (FT-IR) spectrometer analysis 283.4.8 Thermogravimetric analysis (TGA/DTG) 283.4.9 Antioxidant s
tability during storage 293.4.10 In vitro release studies 313.5 Electrospinning system 343.5.1 Preparation of curcumin-jelly fig nano-fibrous mats (C-JFMs) 343.5.2 Determination of the stability of C-JFMs emulsions 373.5.3 Scanning electron microscope (SEM) analysis 373.5.4 Fourier transform
infrared (FT-IR) spectrometer analysis 383.5.5 Thermogravimetric analysis (TGA/DTG) 383.5.6 Calculation of encapsulation efficiency 393.5.7 Antioxidant stability during storage 443.5.8 In vitro release studies 46Chapter 4. Results and discussions 474.1 Electrospraying system 474.1.1 C
onductivity measurement of C-JFCs emulsions 474.1.2 Viscosity of emulsions before electrospray 484.1.3 Encapsulation efficiency and drug loading efficiency 494.1.4 Optical Microscopy 504.1.5 Scanning electron microscope (SEM) after electrospray 544.1.6 Fourier Transform Infrared (FT-IR) 564.1.
7 Thermal analysis (TGA/DTG) 584.1.8 Antioxidant stability 624.1.9 In vitro release studies 634.2 Electrospinning system 654.2.1 Optical microscopy (OM) before electrospinning 654.2.2 Creaming index (CI) 684.2.3 Dynamic light scattering analysis (DLS) 714.2.4 Scanning electron microscope (SE
M) 734.2.5 Fourier transform infrared (ATR-FTIR) 764.2.6 Thermal analysis (TGA/DTG) 784.2.7 Encapsulation efficiency 794.2.8 Antioxidant stability during storage 804.2.9 In vitro release studies 81Chapter 5. Conclusion 86References 87