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An Unwanted Guest

為了解決Storm cellar的問題，作者Lapena, Shari 這樣論述：

AN INSTANT NEW YORK TIMES BESTSELLER The twisty new thriller from the New York Times bestselling author of The Couple Next Door and A Stranger in the HouseA weekend retreat at a cozy mountain lodge is supposed to be the perfect getaway . . . but when the storm hits, no one is getting awayIt's winter

in the Catskills and Mitchell's Inn, nestled deep in the woods, is the perfect setting for a relaxing--maybe even romantic--weekend away. It boasts spacious old rooms with huge woodburning fireplaces, a well-stocked wine cellar, and opportunities for cross-country skiing, snowshoeing, or just curli

ng up with a good murder mystery. So when the weather takes a turn for the worse, and a blizzard cuts off the electricity--and all contact with the outside world--the guests settle in and try to make the best of it. Soon, though, one of the guests turns up dead--it looks like an accident. But when a

second guest dies, they start to panic. Within the snowed-in paradise, something--or someone--is picking off the guests one by one. And there's nothing they can do but hunker down and hope they can survive the storm--and one another. Shari Lapena is the internationally bestselling author of the t

hrillers The Couple Next Door, A Stranger in the House and An Unwanted Guest, which have all been both New York Times and UK Sunday Times bestsellers. Her books have been sold in 35 territories around the world. She lives in Toronto.

Storm cellar進入發燒排行的影片

有益微生物的真菌學和細菌學研究： 在農業和人類健康中的應用

為了解決Storm cellar的問題，作者范明新 這樣論述：

近來從研究發現微生物可以進行改造，以調節植物抵抗禦環境的防禦機制，並強烈增強植物的生長和健康。木腐蘑菇在木質纖維素培養基中可促進植物生長並有提高農業生產力的潛力，杏鮑菇是存在於自然界的白色腐生性的真菌菌株，研究發現其可持續的在30oC和pH 5的環境下將10 mM L-色氨酸（TRP）轉化為酪氨酸-3-乙酸（IAA），跟其它的杏鮑菇種相比，杏鮑菇更適合在更適合於亞熱帶和熱帶氣候生長。真菌在纖維素存在會使用IPA途徑合成IAA，但是環境中高濃度的外源IAA（10 µg / mL）可能會抑制真菌的生長，IAA在單子葉植物（大米）中，發現會增加側根的數量，而在雙子葉植物（番茄）中，根的長度會增長，

通過實驗證明了對線蟲有吸引力和毒性。杏鮑菇有較佳的草酸溶解在菌絲體的區域有氧化物修飾的基質（CaO和ZnO）。在體外試管雙重培養實驗中發現肺假單尖孢鐮刀菌和霍亂單胞菌有拮抗作用，這些新發現及影響可能為在農業中的應用帶來新的見解。相反，Marasmius palmivorus在台灣的福爾摩沙棕櫚（Arenga engleri）樹木上產生症狀，從而使棕櫚樹分枝桿菌在棕櫚種植園中的危害比以往預期的要大。近來研究發現人體腸道細菌中檢測到電子產生可能與人體健康密切相關，腸系膜十二指腸菌Leuconostoc mesenteroides可促使亞油酸發酵來當作電子抗氧化機制，連續6週攝入高脂飲食（HFD）會

誘導的ROS（活性氧）的產生，脂肪細胞3T3-L1分化過程中，脂質積累的增加與ROS的釋放同時發生，這些可能都與腸系膜十二指腸菌誘導的亞油酸發酵產生的電子有關，提供對脂肪形成過程中脂質積累和ROS產生以及高脂飲食誘導的ROS的抑製作用，此外Cyclophilin A蛋白在腸道中可抑制電子產生的產生，我們的研究結果表明，腸系膜十二指腸菌藉由亞油酸的發酵的通過電子產生抑制ROS和脂質的產生，而電子產生受Cyclophilin A蛋白調節。膜糖蛋白是嚴重急性呼吸系統綜合症冠狀病毒2（SARS-CoV-2）的最豐富蛋白質，但其在2019年冠狀病毒病（COVID-19）中的作用機制尚未完全。與綠色熒光蛋

白 (GFP)的小鼠相比，鼻內接種膜糖蛋白的小鼠在支氣管肺泡灌洗液（BALF）白細胞介素-6增加，白細胞介素-6是細胞因子風暴的標誌。膜糖蛋白誘導的高水平的白細胞介素-6在磷酸二酯酶4（PDE4B）敲除小鼠中顯著降低，證明了PDE4B在白細胞介素-6信號傳導中的重要作用。鼠李糖乳桿菌EH8菌株的菌絲體發酵產生了丁酸，它可以下調巨噬細胞中PDE4B的表達和IL-6的分泌。用菌絲體餵養小鼠可增加鼠李糖乳桿菌的相對豐度。鼠李糖乳桿菌和菌絲體補充兩週後，可大大降低膜糖蛋白誘導的PDE4B表達和IL-6分泌。鼠李糖乳桿菌和菌絲體對膜糖蛋白的益生菌活性在用游離脂肪酸受體2 (Ffar2) 拮抗劑GLPG-

0974處理的小鼠中被取消。 Ffar2在腸肺軸中的激活以下調PDE4B-IL-6信號傳導可能為開發包括益生菌在內的治療包括COVID-19中細胞因子風暴的治療方法提供靶點。

In the Dark

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為了解決Storm cellar的問題，作者Piemonte, Rosemarie 這樣論述：

The Falling Roses Saga continues with In the Dark ... "I love my half-sister. Love her too much. And I know she loves me." The Ravolie, Shedel, and Rolando families reunite and collide for a journey that will form their destiny for a future of happiness. Gabrielle Ravolie wants to have a baby. She w

ill make sure her husband John knows she's serious by walking through the kitchen naked in front of their friends. To conceive, she'll even stop taking her medication, but one thing she won't do is take off her shirt. Robbie Shedel comes back from the dead too scared to tell his family he's alive, w

hile Jackie Ravolie-Edilson runs out of ideas for happiness, until meeting Jason Roberts who comes to her with a secret too-his identity. Elizabeth Malone-Shedel comes home from cosmetic surgery and is trapped in a storm cellar by her twin sister, when J.J. comes home to his new wife-Maureen. Nothin

g is wrong with being in love with your half-sister, but it's sick to have a cousin sleeping with your aunt and abducting newborn babies together, especially when they are targeting your niece or... "But then again, my biological inheritances- don't really matter much to to me." www.falling-roses.co

m

石墨烯量子點作為標靶治療大腸癌與神經母腫瘤細胞的新型奈米載體

為了解決Storm cellar的問題，作者林祐生 這樣論述：

摘 要 IAbstract III致 謝 VI目 錄 VII圖目錄 XII表目錄 XXVII第1章 前言 11.1 研究緣起 11.2 研究內容及流程圖 3第2章 文獻回顧 52.1 藥物傳遞系統(drug delivery) 52.2 基因治療 72.2.1 核酸載體之簡介 92.2.2 病毒型載體 112.2.3 非病毒型載體 142.2.4 非病毒載體傳遞機制 252.3 奈米粒子包覆材料 292.3.1 長鏈蛋白質及胺基酸包覆材 292.3.2 有機金屬架構物包覆材料

322.3.3 高分子包覆/修飾材料 352.3.4 小角度散射在軟物質研究上的應用 382.3.5 X光 (SAXS)及中子(SANS)小角度散射應用 442.4 奈米材料藥物釋放 482.4.1 奈米藥物治療 502.4.2 奈米材料藥物釋放—金奈米粒子 532.4.3 奈米材料藥物釋放—銀奈米粒子 562.4.4 奈米材料藥物釋放—磁性材料 572.4.5 奈米粒子藥物釋放—碳材料 592.5 石墨烯家族簡介 602.5.1 石墨烯家族應用在藥物釋放領域 622.5.2 石墨烯與氧化石墨烯藥物釋放 622.6 量

子點家族簡介 652.6.1 量子點發光機制 672.6.2 量子點之製備 692.6.3 量子點藥物釋放之應用 722.7 石墨烯量子點簡介 742.7.1 石墨烯量子點之結構 742.7.2 石墨烯量子點發光機制 762.7.3 石墨烯量子點之製備 782.7.4 石磨烯量子點之藥物釋放 802.8 石墨烯量子點在生醫上的應用潛力 822.8.1 藥導引治療(targeted drug delivery) 822.8.2 生物成像(Bio-image) 822.9 神經母細胞瘤和神經母細胞瘤靶向奈米藥物研究 84

第3章 實驗設備及流程 863.1 實驗藥品 863.2 實驗裝置與工具 873.3 非病毒型載體之製備 883.3.1 燒解法合成石磨烯量子點(Prolysis) 883.3.2 水熱法合成石磨烯量子點(Hydrothermal) 893.3.3 水熱法合成氮參雜石磨烯量子點(Hydrothermal N-GQDs) 903.3.4 微波加熱法合成氮參雜石磨烯量子點 (Microwave N-GQDs) 913.3.5 高分子PEI化之N-GQDs 923.3.6 高分子PEG化之N-GQDs 933.3.7 一步合成P

EG: b-PEI@N-GQDs 943.3.8 兩步高分子化N-GQDs (Two-step polymerized N-GQDs) 953.4 分析及性質測試之儀器介紹 963.4.1 X光粉末繞射儀(XRD) 963.4.2 動態光散射分析儀(DLS) 983.4.3 高解析穿透式電子顯微鏡(HR-TEM) 1003.4.4 紫外-可見光譜儀(UV-Visible) 1023.4.5 傅立葉轉換紅外線光譜分析(FT-IR) 1033.4.6 X光光電子光譜儀(XPS) 1063.4.7 熱重量分析儀(TGA) 1083.4.8

拉曼光譜儀(Raman) 1103.4.9 小角度中子散射 (SANS) 1123.4.10 光致發光光譜儀(Photoluminescence, PL) 1143.5 細胞與生物測試實驗 1163.5.1 細胞測試(MTT assay) 1163.5.2 細胞測試(LDH assay) 1183.5.3 抗體接枝實驗 120第4章 結果與討論 1214.1 特性鑑定及分析 1214.1.1 XRD晶體結構鑑定 1224.1.2 XPS表面元素分析 1314.1.3 TGA 熱重損失分析 1394.1.4 DLS奈米粒子粒

徑分析 1404.1.5 Zeta Potential界達電位 1484.1.6 HR-TEM結構鑑定 1514.1.7 SANS小角度中子散射 1604.2 官能基鑑定 1764.2.1 FT-IR傅立葉紅外線光譜官能基分析 1764.2.2 Raman拉曼吸收光譜分析 1804.2.3 UV-Vis 紫外光-可見光光譜吸收 1834.2.4 PL光激發螢光頻譜 (Photoluminescence) 1914.3 體外細胞(in vitro)測試 2134.3.1 神經母腫瘤細胞BE2M17細胞分析(MTT & LDH assay

)載體鑑定 2144.3.2 大腸癌細胞SW480細胞分析(MTT & LDH assay) 載體鑑定 2304.3.3 細胞SW480與BE2M17之比較 2394.4 體內動物(in vivo)測試 2494.4.1 共軛焦生物成像(Confocal Bio-imaging)測試 2494.4.2 動物體內生物成像(in Vivo Bio-imaging) 2524.4.3 GD2抗體特異性標靶癌細胞 255第5章 結論及未來研究方向 2715.1 結論 2715.2 未來研究方向 273參考文獻 275