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Differential Diagnoses in Surgical Pathology: Non-Neoplastic Dermatopathology

為了解決Systematically的問題，作者Cook, Deborah L. 這樣論述：

Offering expert, practical guidance through the decision-making process, Differential Diagnoses in Surgical Pathology: Non-Neoplastic Dermatopathology, by Dr. Deborah L. Cook, helps you systematically solve tough diagnostic challenges in skin pathology and arrive at a correct diagnosis between co

mmonly confused entities. In this all-new title, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the aut

hor emphasizes atypical features that can complicate diagnoses. Provides side-by-side comparisons for each major differential diagnosis, helping you distinguish between commonly confused non-neoplastic dermatopathology lesions Contains more than 850 full-color photographs that depict the features of

each entity and cover major differential diagnoses in this challenging area Covers inflammatory disorders and alterations of the epidermis and dermis, blistering diseases, disorders of the adnexae and subcutis, infectious diseases, and more Ideal for practicing pathologists, pathologists in trainin

g, residents, and medical students Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Systematically的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Homer’’s Iliad. Book VII

為了解決Systematically的問題，作者Wesselmann, Katharina 這樣論述：

Since Ameis-Hentze-Cauer (1868-1913) no comprehensive, scholarly commentary of Homer’s Iliad has been published in German. In the meantime considerable progress has been made in many traditional areas of Homeric studies (language, realia, structure etc.). In addition, generally acknowledged new f

ields such as narratology have been systematically studied. Furthermore, the knowledge of the Mycenaean language (Linear B) and oral poetry provide completely new possibilities of textual constitution and analysis. Using the old Ameis-Hentze-Cauer as a starting point, the new commentary reflects the

current scholarship on Homer in a comprehensive way. As a new standard work, the ＂Basel Commentary＂ of the Iliad has received considerable recognition among scholars worldwide. The fresh concept in terms of content and form serves the needs of different groups of users. The commentary primarily aim

s at students and academic teachers (at schools and universities), not only of Classics but also of cultural and literary studies as well as of humanities in general.

私域流量虛擬品牌社群價值共創行為研究—以企業運營的視角

為了解決Systematically的問題，作者蔣澤楷 這樣論述：

中國大陸移動互聯網用戶達到高峰，各行業之間的流量爭奪戰也愈發激烈。 在這種背景下，「私域流量」的概念逐漸被許多企業熟知，並建立相關私域流量 虛擬品牌社群。此外，隨著消費者與企業之間的角色從被動到主動的轉變，企業 與消費者共同創造價值也已成為企業獲取競爭優勢的來源。目前的文獻大多以具體案例探討企業應該如何運營管理私域流量虛擬品牌 社群，尚未有學者從企業運營的視角，系統性的研究私域流量對虛擬品牌社群價 值共創行為的動機和後續影響進行研究。本研究將私域流量虛擬品牌社群價值共創行為分為企業-消費者之間的價值 共創行為和消費者-消費者之間的價值共創行為。根據 590 份網路問卷發現，消 費者參與私域流

量虛擬品牌社群的動機中，信息動機、社交動機和娛樂動機正向 影響企業-消費者之間的價值共創行為，信息動機、社交動機正向影響消費者-消 費者之間的價值共創行為。私域流量虛擬品牌社群運營正向影響消費者的品牌信 任，品牌信任在私域流量虛擬品牌社群運營和社群價值共創行為之間的關係發揮 著中介作用。此外，私域流量虛擬品牌社群價值共創行為正向影響品牌認同，品 牌認同正向影響品牌承諾。本研究對私域流量虛擬品牌社群價值共創行為進行了 探索性研究，豐富了私域流量虛擬品牌社群價值共創行為的理論成果。