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徙：臺灣當代詩人十三家(中英對照)

為了解決Taiwan landscape的問題，作者陳義芝,陳克華等 這樣論述：

　　《徙：臺灣當代詩人十三家》收錄的作品緣起美國詩人喬治‧歐康奈爾在臺大外文系開設的臺灣現代詩英譯工作坊。讀者既能從這本雙語詩集中領略到溯源於中國古典詩歌的幽微之境，也能體會到臺灣現代詩在經歷了西方浪漫主義、超現實主義，以及後現代等流派的浸潤之後所展現的多重風貌。 　　本書13位作者為：陳義芝、陳克華、陳黎、陳育虹、鴻鴻、零雨、商禽、吳晟、瘂弦、楊佳嫻、楊牧、顏艾琳、周夢蝶 (按目錄順序)。  

Taiwan landscape進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Taiwan landscape的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

閱讀地景的五個維度

為了解決Taiwan landscape的問題，作者王光宇 這樣論述：

　　作者從事地景專業實務以及專業教育工作許多年，希望藉由從概念性層面談地景（landscape）來提升專業能力的認知。本書強調地景專業力的養成，不只包括規劃設計的知識技術，還包括看事情與看環境的角度。內容分為八個篇章：1.地景的基本概念、2.地景的五個維度、3.地景的第一維度：看得見摸得著的地景、4.地景的第二維度：文化解讀的地景、5.地景的第三維度：感覺的地景、6.地景的第四維度：涵構關係的地景、7.地景的第五維度：整體動態進行的地景、8.從五個維度開啟地景專業新視野。「閱讀地景」包括對地景的觀點與審美，同時經由梳理地景的概念，為地景建築（landscape architecture）拓

展專業新視野。

探討發展都市農園於改善熱島效應-以旱溪為例

為了解決Taiwan landscape的問題，作者張玟豫 這樣論述：

台灣地狹人稠，人口和產業朝向都市集中的趨勢更為明顯，都市化程度已高達 79.9％。行政院經濟建設委員會所建構的「台灣永續發展指標系統」中也特別區分出都市台灣 (Urban Taiwan) 的體系，足見都市的發展攸關整體環境的永續性。美國亞利桑那州立大學聯合全球各地的大專機構，透過大數據的蒐集，計量倘若全球各城市全面實施都市農業，每年可生產多達1.8億噸糧食，也可以緩解都市熱島效應，本研究針對都市農園之永續發展以旱溪的鳥竹圍公園為例進行設計，藉由台中市政府推行的綠美化政策提升人均綠地面積，針對旱溪周遭綠地與裸地和公園尋找適合的場地，研究工具應用都市設計審議綠化量得降溫有效的計算，對都市熱

島效應的了解，從一個綜觀的角度來檢視都市的發展是否符合環境永續性的要求，包括能源使用、水泥化程度、綠覆率、水循環和空氣污染等。若能在都市閒置土地增加農園，便能為當地帶來糧食生產與經濟效益，易能減緩都市熱島效應。