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Saint Young Men Omnibus 11 (Vol. 21-22)

為了解決The ones的問題，作者Nakamura, Hikaru 這樣論述：

The divine live among us...in a flat in western Tokyo! After centuries of hard work, Jesus and Buddha take a break from their heavenly duties to relax among the people of Japan, and their adventures in this lighthearted buddy comedy are sure to bring mirth and merriment to all!Buddha the Enlighte

ned One and Jesus, Son of God have successfully brought the 20th century to a close, and after a few millennia of guiding humanity to salvation, these two sacred ones are in need of some rest and relaxation. They decide to share an apartment on Earth in Tokyo, but living among mortals in the 21st ce

ntury is no cakewalk for the saintly duo... They may find it difficult to navigate modern Japanese living, but Jesus’ carefree attitude along with Buddha’s domestic qualities and maybe a few divine interventions will surely allow them to enjoy their new lives with peace and love.

The ones進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決The ones的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Horses & Ponies: Learn to Draw Using Basic Shapes--Step by Step!

為了解決The ones的問題，作者Walter Foster Jr Creative Team 這樣論述：

With I Can Draw: Horses & Ponies, young artists can use basic shapes and easy-to-follow, step-by-step projects to draw 15 of their favorite equines. A jumping horse, a prancing horse, and a Shetland pony are just some of the drawing projects included in this book. With 15 fun drawing projects

, I Can Draw: Horses & Ponies is a collection of some of kids’ most loved equines. All of the drawings are created with simple shapes that are easy for young artists to make, and the cute, simple illustrations are appealing and approachable to young ones. The book begins with an introduction to

drawing materials and instructions on how to use the book, and then it jumps right into the drawing projects. For a cute pony: Kids start with a rectangle, add a line, a curved line, and some more straight and curved lines. They are encouraged to keep following along with each step. As they make

their way through the multiple steps, all the new pencil marks to make are shown in a different color so it’s easy to know what to draw next. Once they near the end of the project, these young artists will start to see a drawing of a pony appear on their paper, and all they need to do now is add so

me color. Great job! Each title in the I Can Draw series features easy step-by-step drawing lessons for little artists. Starting with basic shapes, such as a square, a rectangle, a triangle, and a circle, children will discover how to draw a range of subjects, including animals, butterflies, flowe

rs, pets, and more! The books in the I Can Draw series provide the perfect introduction to drawing for budding artists. Have even more drawing fun with: I Can Draw: Wild Animals, I Can Draw: Favorite Pets, I Can Draw: Cats & Kittens, I Can Draw: Everything Cute & Cuddly, I Can Draw: Dogs &

amp; Puppies, I Can Draw: Princesses & Fairy Tales, I Can Draw: Birds & Butterflies, I Can Draw: Dinosaurs, and I Can Draw: Cars, Trucks, Trains & Planes.

智慧教室融入語文教學的學習成效之研究

為了解決The ones的問題，作者李玉琳 這樣論述：

因應新北市2030年智慧城市的計畫，校園中積極增設智慧教室，本研究針對「智慧教室」在課堂上與語文領域的教學做結合運用研究，目的在研究智慧教室對於語文領域的科目是否能提高學習成效，學生對於智慧教室的學習滿意度，以及智慧教室是否影響學習態度。本研究使用準實驗法，研究對象為新北市中和區某國小六年級的學生50名，透過教學實驗前測、教學實驗、教學實驗後測、課程回饋問卷，並以SPSS 21做資料分析。研究結果顯示：實施智慧教室融入語文領域教學後，學生在語文領域學習成效上，前測成績與後測成績有顯著差異。實施智慧教室融入語文領域教學後，實驗組的後測成績與對照組的後測成績無顯著差異。實施智慧教室融入語文領域教

學後，實驗組在課程回饋上，實驗組學生使用智慧教室融入教學中滿意度均高於均值，學習態度之影響各項分數也高於平均值，針對回饋問卷的兩個向度，實驗組均持高度正向的評價。根據本研究結果，教學現場的老師的角色很重要，適當的應用智慧教室，可以提升學生學習成效，適應個別差異，達到十二年國教自發、互動、共好，建議教學現場老師需再進修，研發出可廣泛應用的教學設計，協助學生更有效率的學習，未來研究者可以繼續研究智慧教室在不同領域中的應用創新，以造福後進。