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Rural Route 8 Part 2: Unrequited Love

為了解決Wound up的問題，作者Turonek, E. Raye 這樣論述：

In this tantalizing thriller of lust, jealousy, envy, murder, and mayhem you’ll see that nothing stands in the way of unrequited love. Not even spouses...With the dust settling on tragic events that took place just months prior in Clarkston, the residents of the small yuppie town press forward, carr

ying on their mundane lives as if the puzzling string of murders hadn’t taken place. Still, there is one person unable to go back to the way things were. How can she? Evelyn Todd has woken up not knowing her true identity or how she wound up in that hospital bed with wires attached to every extremit

y as if she were some sort of lab experiment. What she is convinced of is her love for Colin Ravish--no matter how much her family and friends regale her with stories of her loving marriage to her doting husband, Erick. Over time, Evelyn’s obsession with the part-time paramedic only grows stronger,

threatening the beautiful union she’d built up until the night she was attacked and her memory washed away. Erick refuses to give up on the love of his life and mother of his children. How far is he willing to go to pull his wife back from the brink of disaster? That depends on how far Evelyn is wi

lling to go to win the object of her affections. E. Raye Turonek is a married mother of five. The Detroit, Michigan native resides with her husband and family in a small rural town in Michigan. Since releasing her debut literary work, Compelled to Murder, in 2016 the author has penned two more nov

els and also publishes a monthly newsletter highlighting all things literary--as well as astrology forecasts. This multifaced author is looking to fulfill the reader’s need for a sensational experience that won’t be forgotten.

Wound up進入發燒排行的影片

有限元素法模擬醫療元件周圍之細胞行為：以骨釘與水膠為例

為了解決Wound up的問題，作者鄭厚雍 這樣論述：

近年來，牙釘和水膠在臨床醫療上被廣泛地研究與討論，故本論文選擇這兩種醫療元件作為研究對象。(1) 牙釘：牙釘的幾何結構經研究證實會大幅地影響骨整合與骨癒合。然而，尋找一個具最佳幾何結構的牙釘是十分費時的。因此，本論文提出一套結合深度學習網路、細胞分化理論、隨機森林演算法與基因演算法的牙釘結構最佳化設計系統。其能夠在2.5秒內預測牙釘周圍的細胞分化情形，並基於螺紋間骨釘和骨頭的接觸長度以及骨頭長入的面積比來最佳化骨釘的骨癒合能力。經過基因演算法的多次迭代後，研究成功取得具優秀骨整合效率的最佳化牙釘，其結構的特色主要為牙釘中上段部分不具有明顯的螺紋結構。(2) 水膠：由於高生物相容性

、與天然細胞相似的材料性質，使得合成水膠被大量應用於組織工程中。但是水膠基板的外觀設計與受到之力學刺激會對其內部細胞的遷移行為有極大的影響，這使得水膠基板的細胞行為研究就顯得格外重要。本論文藉由有限元素軟體Abaqus探討水膠的拉伸應力、應變，以及觀察水膠局部區域的細胞移動行為。前者的研究成功呈現與實驗水膠基板相同的形變過程，並發現細胞的移動行為與水膠的應力分布有關。而後者的研究則利用Abaqus中的光滑粒子流體動力學模型，成功展現水膠中不同區域的細胞會有不同移動與聚散行為的現象。

Power Failure: The Rise and Fall of General Electric

為了解決Wound up的問題，作者Cohan, William D. 這樣論述：

The dramatic rise--and unimaginable fall--of America’s most iconic corporation by New York Times bestselling author and pre-eminent financial journalist William D. CohanNo company embodied American ingenuity, innovation, and industrial power more spectacularly and more consistently than the General

Electric Company. GE once developed and manufactured many of the inventions we take for granted today, nearly everything from the lightbulb to the jet engine. GE also built a cult of financial and leadership success envied across the globe and became the world’s most valuable and most admired compan

y. But even at the height of its prestige and influence, cracks were forming in its formidable foundation. In a masterful re-appraisal of a company that once claimed to ＂bring good things to life,＂ pre-eminent financial journalist William D. Cohan argues that the incredible story of GE’s rise and fa

ll is not only a paragon, but also a prism through which we can better understand American capitalism. Beginning with its founding, innovations, and exponential growth through acquisitions and mergers, Cohan plumbs the depths of GE’s storied management culture, its pioneering doctrine of shareholder

value, and its seemingly hidden blind spots, to reveal that GE wasn’t immune from the hubris and avoidable mistakes suffered by many other corporations. In POWER FAILURE, Cohan punctures the myth of GE, exploring in a rich narrative how a once-great company wound up broken and in tatters--a caution

ary tale for the ages. A former Wall Street investment banker for 17 years, William D. Cohan is the New York Times bestselling author of The Price of Silence, Money and Power, House of Cards, and The Last Tycoons, which won the 2007 FT/Goldman Sachs Business Book of the Year Award. He also wrote

Four Friends: Promising Lives Cut Short and Why Wall Street Matters. He was a longtime special correspondent at Vanity Fair and is a founding partner of Puck, a new digital media venture. He also writes often for the opinion pages of The New York Times and The Financial Times and he isa writer-at-l

arge for AirMail. Over the years, he has also written for Bloomberg Businessweek, Fortune, The Atlantic, Institutional Investor, The New York Times, The Nation, and TheWashington Post, among other publications. Cohan is a graduate of Duke University, the Columbia University School of Journalism, an

d the Columbia University Graduate School of Business.

Melatonin inhibits chondrosarcoma cell metastasis by suppressing MMP7 expression

為了解決Wound up的問題，作者NGUYEN BAO TRAN 這樣論述：

Chondrosarcoma is rare but has intense metastasis and limited response to chemotherapy and radiation treatment. Enzymatic activity of matrix metalloproteinase (MMP) family members has an important role in chondrosarcoma metastasis. Melatonin exhibits anticarcinogenic activity in many types of cance

rs by suppressing the expression of certain MMP family members, but this has not been clearly determined as yet in chondrosarcoma. Using a human protease array kit, this study analyzed the protein expression of two chondrosarcoma cell lines (JJ012 and SW1353) with and without melatonin treatment, re

vealing that matrix metalloproteinase-7 (MMP7) was among the top three proteins suppressed by melatonin. Further cell experiments showed that melatonin effectively suppresses proliferative and metastatic activities in chondrosarcoma cells. Moreover, melatonin suppressed anoikis resistance, as determ

ined by anchorage-independent growth under suspension conditions in an anoikis assay and by low quantities of chondrosarcoma cells in the circulation of an in vivo study. In nude BALB/c mice, melatonin significantly inhibited tumor growth and lung metastases. Cell culture revealed that overexpressio

n of MMP7 significantly promoted chondrosarcoma cell proliferation and migration, which was significantly inhibited by melatonin. A subsequent tissue array demonstrated significantly higher levels of MMP7 expression in chondrosarcoma tissue compared with normal cartilage tissue specimens; chondrosar

coma disease stage/grade was correlated with MMP7 expression. Next, a comparison of micro-RNA (miRNA) expression profiles of melatonin-treated and melatonin-untreated chondrosarcoma cells identified that several miRNAs were up-regulated in the melatonin-treated cells. A computational prediction was

performed using four publicly available miRNA databases (TargetScan, miRanda, miRMap and miRWalk) to predict miRNA targeting MMP7. The intersection of 11 candidate miRNAs identified miR-520f-3p as the most up-regulated miRNA in response to melatonin. Thus, our study suggests that melatonin reduces M

MP7 synthesis, chondrosarcoma cell motility and metastasis via the miR-520f-3p/MMP7 axis.Keywords: Chondrosarcoma, proliferation, metastasis, melatonin, MMP7, miR-520f-3p