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在神經膠質瘤減弱KDELC2抑制細胞的增生、爬行及侵襲能力

為了解決jenny yn的問題，作者王貞懿 這樣論述：

多型性神經膠質母細胞瘤(Glioblastoma multiforme，簡稱GBM)，為最常見的原發性惡性腦瘤，病程惡化速度快、腫瘤浸潤性高、手術不易完全清除乾淨，成為神經膠質瘤(Glioma)中惡性程度最高的腫瘤，而目前多型性膠質母細胞瘤的標準治療方式是手術後同步藥物與放射治療，但中位存活時間也頂多延長至15個月，5年存活率僅有3~5%，預後仍不盡理想。且外科手術治療無法在不傷害到正常腦細胞的前提下將腫瘤完全清除，對於病人治療是很大的阻礙；而在化學治療方面，觀察到的結果到後期，病人多數會產生抗藥性，使化療無法順利進行，且在新藥開發上，還得先克服血腦屏障的阻滯，使得在新藥研發上相較於

其他癌症，難上加難。因此，基因治療對於神經膠質瘤的病患或許是種新選擇。 近年來，NOTCH的異常激活與腫瘤過程有關。 NOTCH信號傳導的機制與腫瘤病理性血管生成有關。作為NOTCH訊息途徑的調節者，我們想檢測KDELC2是否可以被視為對GBM產生更佳治療效果的標的。 先前已有實驗以KDELC2為目標基因，以蛋白質印跡，即時聚合酶鏈反應和免疫化學組織染色來觀察KDELC2與正常腦組織間表現量的差異，且發現KDELC2的表現量多寡與世界衛生組織(WHO)的腫瘤分級具有正相關性。未來的研究方向將透過抑制此基因，觀察腫瘤細胞生長速率、侵襲能力、惡性程度等影響，以及此基因可能牽涉的相關生化

路徑。關鍵字: 神經膠質瘤、細胞增生、細胞爬行、細胞侵襲。

台灣中老年人飲食模式與腎臟功能障礙之關聯：2008年至2010年的橫斷研究

為了解決jenny yn的問題，作者盧卡思 這樣論述：

Objective: Chronic Kidney Disease (CKD), characterized by impaired kidney function, affects over 1.5 million individuals in Taiwan. Low testosterone levels, cardiovascular disease (CVD), dyslipidemia, anemia, and low-grade inflammation are commonly found in impaired kidney function CKD subjects. Si

nce diet plays an important role in the development of the outcomes of CKD aforementioned, our study was designed to investigate the association of dietary patterns with testosterone levels, cardiovascular risk factors, dyslipidemia, anemia, and the severity of impaired kidney function in middle-age

d and older adults in Taiwan.Methods: 41,128 participants aged more than 40 years old with an estimated glomerular filtration rate (eGFR) less than 90 mL/min/1.73 m2 and positive urinary protein were recruited from Mei Jau Health Institute between 2008 and 2010. The dietary patterns were identified

using principal component analysis (PCA) and reduced rank regression (RRR) method was used to determine the kidney function-, inflammatory-, and metabolic syndrome (MetS) - related dietary pattern. A multivariable linear regression analysis was used to identify the association between dietary patter

ns derived by PCA with testosterone levels and kidney function biomarkers. While, a multivariable logistic regression analysis was used to identify the association between dietary pattern derived by RRR with the severity of impaired kidney function, cardiovascular risk factors, dyslipidemia, anemia,

and MetS components.Results: Males with higher tertile of fried-processed dietary pattern score was associated with decreased testosterone levels by 0.8 nmol/L (95% CI: -1.40, -0.16), reduced testosterone-to-TG (T/TG) ratio by 1.8 units (95% CI: -2.99, -0.53), and increased risk of moderate/severe

decline in kidney function (eGFR < 60 mL/min/1.73 m2) by 1.35 (95% CI: 1.15, 1.58). The kidney function-related dietary pattern characterized by frequent intakes of preserved or processed food, meats and organ meats, rice and flour products, and low intakes of fruit, dark-colored vegetables, bread,

and legumes or beans. In both genders, high adherence of dietary score was correlated with 2.07 times (95% CI 1.89–2.27) risk of obese weight status, 10 to 31% risk of cardiovascular risk, and 1.15 times (95% CI 1.02–1.29) risk of moderately or severely impaired kidney function. The higher adherence

of inflammatory dietary pattern (low intakes of seafood, grains, vegetables, and fruit but frequent intakes of meats, eggs, preserved or processed food, and sweet drinks) was associated with increased 21% risk of dyslipidemia in males and increased 35% - 47% risk of anemia in both genders. There wa

s an association between high consumption of inflammatory dietary pattern with reducing eGFR (males and females; β = -0.85 and -0.53, p < 0.05 respectively) and increased CRP level and/or neutrophil-to-lymphocyte (N/L) ratio in both genders. Moreover, compared with PCA method, RRR shows stronger sta

tistical associations with MetS.Conclusion: Our findings suggest that high intakes of processed and animal foods and low intake of seafood and plant foods predict the risk for developing hypogonadism, cardiovascular disease, dyslipidemia, anemia, and rapid kidney function decline.