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Arthur Frommer’’s Europe

為了解決julia的問題，作者Frommer, Arthur,Ames, Paul,Barron, Peter 這樣論述：

Arthur Frommer The son of a Polish-born mother and an Austrian-born father, Frommer was drafted into the U.S. Army during the Korean War, but was stationed in Europe because of his fluency in German and Russian. During his service, he wrote and self-published a guidebook called The GI’s Guide to Tra

veling in Europe in 1955 that was an immediate hit among his fellow soldiers. In 1957, Frommer created a civilian version called Europe on 5 Dollars a Day, which became an overnight best seller. He subsequently published guidebooks covering all parts of the globe. Frommer licensed his travel guide b

ook business to Simon & Schuster in 1977. Eventually, the Frommer’s series was purchased by John Wiley & Sons, and in August 2012, Google purchased the travel guides. Through all the exchanges, Arthur Frommer was always deeply involved with the guide books. In 2013, Frommer reacquired control of the

guidebooks bearing his name and has come full circle, now self-publishing his iconic travel books again. Additionally, Arthur Frommer writes a travel column syndicated through King Features, and co-hosts a weekly syndicated radio show with his daughter Pauline, ＂The Travel Show with Arthur & Paulin

e Frommer.＂ Arthur resides in New York City. Paul Ames (author Portugal): A native of England’s East Anglia region, Ames has been fascinated by Portugal since a childhood visit in the 1970s when the country was gripped by revolutionary fervor. After 20 years based in Brussels covering Europe for Th

e Associated Press and other international media, he returned to Lisbon in 2013. Paul works as a freelance journalist and never tires of exploring the delights of his adopted homeland, from the green hills of the Minho to sub-tropical Madeira island and all the beaches in between. Peter Barron (auth

or Spain): After careers at the BBC and Google, Peter Barron turned his attention to restoring a barn with his wife Julia at their finca on the border between Andalucía and Extremadura. He has been visiting Spain for over thirty years and loves flamenco guitar, ibérico ham, and manzanilla sherry. He

is one of the authors of Frommer’s Spain and blogs about Extremaduran life at adventuresinextremadura.com. He divides his time between Spain and London. Anna E. Brooke (author France) relocated from her native Britain to Paris in 2000 and hasn’t looked back since. She is now a full-fledged bohemian

, juggling life between freelance travel writing (Frommer’s, Sunday New York Times Travel, Time Out Paris and the Financial Times), children’s fiction, acting and songwriting for film. Jennifer Ceaser (author Belgium and The Netherlands) is a freelance writer and editor who has specialized in travel

journalism for two decades. A former New Yorker and staff editor at the New York Post, Jennifer has lived in Europe since 2016, including Amsterdam, Berlin and Barcelona. She contributes to a variety of publications including Condé Nast Traveler, AFAR, New York magazine, BBC, Time Out, Delta Sky, a

nd Wine Enthusiast. Jason Cochran (author, England & Scotland) was twice awarded Guide Book of the Year by the Lowell Thomas Awards (Society of American Travel Writers) and once by the North American Travel Journalists Association for his book Frommer’s EasyGuide to London. His writing has appeared

in the New York Post, Entertainment Weekly, Travel + Leisure, USA Today, and Budget Travel , among many others. Jason has appeared as a host and commentator on CBS, Fox and AOL, to name a few. He currently is the Editor in Chief of Frommers.com. Donald Strachan (author Italy) is a writer and journal

ist who has written about Italy for publications worldwide, including National Geographic, the Guardian, Sunday Telegraph, and the Independent. Rachel Glassberg (author Austria, Germany, Switzerland) is a Berlin-based journalist last seen traversing the Alps for Frommer’s Switzerland and ruining he

r friends’ favorite bars for Frommer’s Germany. Formerly deputy editor of the English-language city magazine Exberliner, she now divides her time between writing, music, and travel -- sometimes two or even all three of those simultaneously.

julia進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決julia的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Essays on Aristotle’s Eudemian Ethics

為了解決julia的問題，作者Heinaman, Robert (EDT) 這樣論述：

Two major works on ethics have come down to us under Aristotle's name, the Nicomachean Ethics and the Eudemian Ethics, but, quite unjustifiably, the Eudemian Ethics has been largely neglected by students of ancient philosophy. This important collection of essays from the sixth Keeling colloquium on

ancient philosophy tries to rectify this one-sided approach to Aristotle's ethics by focusing on the positions and arguments of the Eudemian Ethics. As the essays demonstrate, Aristotle's views in the Eudemian Ethics frequently differ in interesting and surprising ways from those found in the Nicoma

chean Ethics and deserve study for their own sake, not merely for purposes of comparison with the Nicomachean Ethics. The contributors include some of the best known Aristotle scholars of the present day. Christopher Rowe and Jennifer Whiting investigate the Eudemian Ethics' account of friendship (p

hilia) while M.M. McCabe examines the closely related issue of self-knowledge in EE VII.12. Stephen White analyzes the Eudemian Ethics' account of eudaimonia, David Charles focuses on voluntary action, and Friedemann Buddensiek investigates Aristotle's difficult discussion of good fortune (eutuchia)

in EE VIII.2. The volume also contains critical discussions of these papers provided by commentators, who, along with Whiting and McCabe, include Julia Annas and Sarah Broadie. Dr Robert Heinaman, Reader in Philosophy, University College London, UK

中年再婚女性婚姻關係中的自主與親密

為了解決julia的問題，作者陳淑雅 這樣論述：

本研究旨在了解中年再婚女性在婚姻關係中，如何展現自主並保有緊密的親密關係，邀請三位中年再婚女性參與研究，並以深度訪談法進行資料蒐集，根據研究結果提供家庭輔導工作者、再婚女性及其伴侶以及未來相關研究者參考。研究結果發現中年再婚女性對再次的婚姻生活，期待能得到另一半的支持與配合，並認為在婚姻關係中劃出清楚界線，並非拒絕溝通，而是讓對方知道如何對待自己，此舉對婚姻有正面的幫助。面對繼親教養的歧異上，表示需藉由不斷的相互對話，了解彼此的想法有助夫妻間的情感增溫。中年再婚女性若能同理或接住另一半的感受，且接納對方和自己的不同，將降低婚姻衝突的頻率，當中年再婚女性能向內覺察自己，也能向外觀照另一半時，夫

妻間的親密關係就能輕鬆自在的發展，也是夫妻關係更親密且自主的關鍵。