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Managing Engineering, Procurement, Construction, and Commissioning Projects: A Chemical Engineer’’s Guide

為了解決project scope的問題，作者Karre, Avinashkumar V.,Sharma, Deepak 這樣論述：

An invaluable real-world guide to managing large-scale and complex Engineering, Procurement, Construction and Commissioning (EPCC) projectsEngineering, Procurement, Construction and Commissioning (EPCC) infrastructure projects require engineers from several disciplines to adhere to strict budgetary,

scheduling, and performance parameters. Chemical engineers involved in EPCC projects are involved primarily in ensuring that the process plant is designed correctly and safely--interacting with the client, contributing to feasibility studies, selecting specific technologies, developing process flow

diagrams, and other key tasks. Managing Engineering, Procurement, Construction, and Commissioning Projects: A Chemical Engineer’s Guide clearly defines the role of a chemical engineer in the EPCC industry and provides detailed and systematic coverage of each phase of an EPCC project. Drawing from t

heir extensive experience in process design, optimization, and analysis, the authors identify and discuss each key task and consideration from a chemical engineer’s perspective. Topics include scope and process planning, construction support, operator training, safety and viability evaluation, and d

etail engineering. Provides a structured overview of the various challenges chemical engineers face in each project phaseIntroduces the essential aspects of the Engineering, Procurement, Construction and Commissioning industryDescribes the roles of chemical process engineers in each phase of EPCC pr

ojects and in different EPCC industry positions Discusses the interaction of process engineers with other disciplines and clientsManaging Engineering, Procurement, Construction, and Commissioning Projects: A Chemical Engineer’s Guide is a must-have resource for chemists in industry, process engineer

s, chemical Engineers, engineering consultants, and project managers and planners working on EPCC projects across the chemical Industry. Avinashkumar Karre is Lead Process Engineer at Worley Group, a global provider of professional project and asset services in the energy, chemicals, and resources

sectors. With more than 13 years of design experience in the Refinery and Chemical industry, Karre has worked on a range of assignments including grassroots process design, process feasibility studies, and process safety analysis.

project scope進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決project scope的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Agile Project Management in Easy Steps

為了解決project scope的問題，作者 這樣論述：

Thisthird edition of Agile Project Management in easy steps hasbeen updated to reflect its ongoing evolution. It explains the principles, practices, and processes of agile project management, by following an entire project, step-by-step, and covering the main activities and deliverables, includin

g: Pre-project foundations, projectvision and the business case.Ongoing discovery and definition of scope. Iterative and incremental development. Continual retrospectives and improvement. Post-project close-down and benefits review.Nowwith four new chapters: The changes from the traditional role and

responsibilities. How to apply agile approaches to projects inmore controlled environments. How the role of project management changes inorganizations moving from projects to continual flow and value streams. Growing trends that project managers canbenefit from today. Anessential guide for anyone ne

w to agile projects and a valuable source ofinspiration for the more experienced.Includesfree downloadable templates to get you started.

系統移轉關鍵因素之實務研究

為了解決project scope的問題，作者陳慧姍 這樣論述：

隨著時代變遷與新業務的多樣化需求，一個行之己久的系統，除了穩定運作之外，系統快速變更的能力也是必需的，面對業務需求的增加及新技術發展，系統移轉開發升級是必然面對的課題，系統移轉前有足夠的溝通及明確的專案範圍定義，可讓系統移轉開發達到事半功倍的效果。本研究目的在針對系統移轉實務開發過程、相關文獻及專案管理知識指南 (PMBOK Guide, A Guide to the Project Management Body of Knowledge)，進行探討系統移轉關鍵指標因素及程式開發者規劃及應對，研究係採用專家訪談問卷並佐層級分析法研究方法分析推論其結果，達成研究結論，共計發出九份專家訪談問卷

，並回收九份，研究歸納結果顯示「系統移轉」關鍵要素計算出的權重比例前三項分別為「組織政策」、「專案目標」及「系統分析」。