韓劇電影你都看哪一部呢？論文書籍站
國立清華大學 化學工程學系 宋信文所指導 李伯偉的 多功能生物可分解奈米粒子做為生醫應用之研究 （2009），提出th-7168fe關鍵因素是什麼，來自於穿皮基因傳遞、生物可分解奈米微粒、基因槍、細胞追蹤、免疫治療、酸鹼敏感性材料、胞飲路徑。
而第二篇論文國立臺灣大學 材料科學與工程學研究所 段維新、Michel DUPEUX所指導 李炤佑的 金屬/陶瓷界面工程:介電陶瓷與金屬電極之接著強度研究 （2006），提出因為有 blister test、interface indentation test、cross-sectional indentation test、銀、鎳、鈦酸鋇、金屬陶瓷界面、接著強度的重點而找出了 th-7168fe的解答。
多功能生物可分解奈米粒子做為生醫應用之研究
為了解決th-7168fe 的問題，作者李伯偉 這樣論述：
As a highly immune-reactive tissue containing an abundance of antigen-presenting cells such as Langerhans cells, skin represents a favorable site for DNA immunization. Previous human clinical studies on the gene gun have demonstrated the feasibility of directly targeting LCs to deliver DNA-coated g
old particles. However, when accumulated, gold particles as a carrier for transdermal gene delivery may incur adverse side effects. In the first part of this study, biodegradable nanoparticles, composed of chitosan (CS) and poly-γ-glutamic acid (γ-PGA), were prepared by an ionic-gelation method for
transdermal DNA delivery (CS/γ-PGA/DNA) using a low-pressure gene gun. Conventional CS/DNA without the incorporation of γ-PGA were used as a control. The internal structures of test nanoparticles were then examined using small-angle X-ray scattering, while their constituents were identified using Fo
urier transformed infrared spectroscopy. CS/γ-PGA/DNA were spherical in shape with a relatively homogeneous size distribution. In contrast, CS/DNA had a heterogeneous size distribution with a donut, rod or pretzel shape. Both test nanoparticles could effectively retain the encapsulated DNA and prote
ct it from nuclease degradation. Compared with CS/DNA, CS/γ-PGA/DNA enhanced their penetration depth into the mouse skin and enhanced the gene expression. Above observations may be attributed to that CS/γ-PGA/DNA were more compact in their internal structures and had a greater density than their CS/
DNA counterparts, thus having a larger momentum to penetrate into the skin barrier. Experimental results indicated that CS/γ-PGA/DNA may substitute gold particles as a DNA carrier for transdermal gene delivery. In the second part of this study, a multifunctional core-shell nanoparticle system was de
veloped, which can be delivered transdermally into the epidermis by a gene gun as a DNA carrier. The developed nanoparticles were consisted a hydrophobic PLGA core and a positively-charged glycol chitosan (GC) shell. Based on use of the core of nanoparticles, fluorescent quantum dots (QDs) were load
ed for ultrasensitive detection of the migration of Langerhans cells once delivered transdermally, while a reporter gene was electrostatically adsorbed onto the GC shell layer of nanoparticles. Results obtained from fluorescence spectrophotometry, transmission electron microscopy, energy dispersive X
-ray analysis, and X-ray diffraction measurement indicated that the prepared nanoparticles had a core-shell structure with QDs in their core area. The surface charge of nanoparticles was strongly dependent on their pH environments, allowing the release of the loaded DNA intracellularly through a pH-
mediated mechanism. Based on use of a mouse model, our results further demonstrated that bombardment of nanoparticles transfected DNA directly into LCs present in the epidermis. The transfected LCs then migrated and expressed the encoded gene products in the draining lymph nodes. Above results sugg
est the feasibility of using the developed nanoparticle system to monitor and fine-tune important functional aspects of the immune system, in conjunction with the loaded fluorescence, thus having the potential for use in immunotherapy and vaccine development. This study also explored the feasibility
of using the CSNP system to develop a MRI constrast. Results of this study demonstrate that an efficient contrast agent for magnetic resonance imaging (MRI) is essential to enhance the detection and characterization of lesions within the body.This study described the feasibility of developing biode
gradable nanoparticles with a core-shell structure to formulate superparamagnetic iron oxide (CSNP-SPIO) for MRI. The developed nanoparticles were composed of a hydrophobic PLGA core and a positively-charged glycol chitosan shell. Results obtained from transmission electron microscopy, energy disper
sive X-ray analysis, electron energy loss spectroscopy, and X-ray diffraction measurement indicated that the prepared nanoparticles had a core-shell structure with SPIO in their core area. Nanoparticles did not aggregate together during storage in water, owing to the electrostatic repulsion between
positively-charged nanoparticles. The magnetic properties of nanoparticles were then examined by a vibrating sample magnetometer and a superconducting quantum interference device. Experimental results indicated that the superparamagnetism of SPIO was preserved after the CSNP-SPIO formulation. Closel
y examining their cellular internalization pathway revealed that CSNP-SPIO accumulated in lysosomes. In the biodistribution study, a high level of radioactivity was observed in the liver shortly after administering the 99mTc-labeled CSNP-SPIO intravenously. Once taken up by the liver cells, the live
r turned dark on T2* images. Following cellular internalization, CSNP-SPIO were broken down gradually. Therefore, as time increased, the darkness of the liver on T2* images significantly decreased. Results of this study demonstrated the developed CSNP-SPIO can serve as an efficient MRI contrast agen
t and could be degraded after serving in their imaging function.
金屬/陶瓷界面工程:介電陶瓷與金屬電極之接著強度研究
為了解決th-7168fe 的問題，作者李炤佑 這樣論述：
本論文是研究金屬與陶瓷界面的機械強度性質，陶瓷是使用商用鈦酸鋇粉，金屬部分為銀膏及鎳膏所製成的金屬膜，膜的成型方是為網版印刷法。使用不同表面性質的緻密鈦酸鋇做為基板，金屬膏覆蓋在陶瓷基板上並在不同溫度下燒結，試片加工製成特殊形狀以符合Blister test的試片形狀要求。Blister test可以得到量化的介面強度，並可由此得出介面裂縫延伸的所需的能量，在實驗過程中會伴隨著塑性變形，在本實驗中我們提出一個簡單的處理方法以減去塑性變形的影響。在不同銀膠燒結溫度下，銀及鈦酸鋇的界面強度落在4 -7 J/m2 之間，鎳及鈦酸鋇的界面強度約為1 J/m2。本實驗中嘗試發展三種 indentati
on 方法來量測相同的金屬與陶瓷界面的強度，經由 normal及 interface indentation 所得出的銀與碳酸鋇的界面強度約為 0.5 J/m2. 第三種測試方法Cross-sectional indentation test 為本研究中發展出的全新測試方法，並提出一種新的理論分析。依照不同的分析模型，所得出的銀與碳酸鋇的界面強度約為 1到3 J/m2.